News

Prostate Cancer Study Identifies Numerous Subtypes of the Disease

  • Prostate cancer is the second most common cancer in men worldwide.
  • Integrative analysis led to the identification of 7 subtypes of prostate cancer.
  • Changes in signaling pathways and DNA repair genes may suggest new opportunities for therapy.

By Lisa Iype

Prostate cancer is the second most common cancer in men worldwide. The clinical behavior of prostate cancer is variable with some men exhibiting indolent prostate cancer which can be monitored over time while other men develop aggressive prostate cancer which can lead to metastasis and death.

Fig5_20150915

Figure from “The Molecular Taxonomy of Primary Prostate Cancer.”

As part of The Cancer Genome Atlas (TCGA) project, ISB researchers helped to analyze 333 primary prostate cancers by integrating data from DNA sequence, gene expression, microRNA expression, protein expression, and DNA methylation profiles. The study identified seven subtypes of prostate cancer reflecting the heterogeneity of this cancer. Approximately one-fourth of the samples could not be readily classified as a particular subtype. In the study, TCGA researchers also identified changes in signaling pathways and DNA repair genes which may suggest new opportunities for therapy.

The TCGA researchers compared their results to results from a recent multi-institutional study on metastatic prostate cancer (Integrative Clinical Genomics of Advanced Prostate Cancer) in order to identify molecular features which were similar and different between primary prostate cancer and treated metastatic prostate cancer. Many genes and pathways had increased alteration rates in the metastatic samples as compared to the primary prostate samples.

Title: “The Molecular Taxonomy of Primary Prostate Cancer”
Journal: Cell
Authors: The Cancer Genome Atlas Research Network
Link: Cell

TCGA Release: Read press release…

Recent Articles

  • ISB researchers

    Unveiling the Guerrilla Warfare Tactics of Mycobacterium Tuberculosis

    ISB researchers have unveiled new insights on how Mycobacterium tuberculosis, the pathogen that causes tuberculosis, enters and exits a dormant state in human hosts. About a quarter of the world’s population has latent TB, so these important findings will enable and accelerate the discovery of more effective TB drugs.

  • Spotlight on Caroline Cannistra, ISB Systems Research Scholar

    Caroline Cannistra joined ISB in 2018 as a Systems Research Scholar. The Systems Research Scholars Program provides recent college undergraduates a springboard to become the next generation’s pioneers of interdisciplinary scientific research.

  • 2019 education awards

    ISB’s Mónica Orellana, Nyasha Chambwe Honored With Inaugural Education Recognition Awards

    At ISB, many of our scientists and STEM professionals give their time and expertise and make profound impacts on our educational programs. Two of our researchers — Dr. Mónica Orellana and Dr. Nyasha Chambwe — were honored with inaugural Education Recognition Awards for their devotion to providing quality STEM education.